Certain 3h-1, 4-benzodiazepin-2(1h)-ones



United States Patent 3,414,563 CERTAIN 3H-1,4-BENZODIAZEPIN-2(1H)-0NES Rudolf G. Griot, Florham Park, N.J., assignor to Saudoz Inc., Hanover, NJ.

No Drawing. Continuation-impart of application Ser. No. 392,905, Aug. 28, 1964. This application Mar. 25, 1966, Ser. No. 537,276

4 Claims. (Cl. 260-2393) ABSTRACT OF THE DISCLOSURE This invention is directed to compounds of the formula:

/ RIII R! wherein R represents lower alkyl R represents lower alkyl R" represents hydrogen or lower alkyl R' represents hydrogen, lower alkyl or phenyl; and

each of R and R independently, represents hydrogen,

halo, lower alkyl, lower alkoxy, loweralkylthio, or loweralkylsulfonyl These compounds are useful as tranquilizers.

This application is a continuation-in-part of my copending application, Serial No. 392,905, filed August 28, 1964, now abandoned.

This invention relates to benzodiazepinones. In particular, the invention relates to benzodiazepinones which are represented by the following structural formula:

wherein R is loweralkyl, preferably containing 1 to 4 carbon atoms,

e.g., methyl, ethyl, propyl or butyl; Y is NH NRR'; OR; --SR'; or a saturated monocyclic ring R is loweralkyl, preferably containing 1 to 4 carbon atoms, e.g. methyl, ethyl, propyl or butyl; allyl; propargyl; diloweralkylaminoethyl, each of the loweralkyl groups thereof preferabl containing 1 to 4 carbon atoms, e.g., S-dimethylaminoethyl; diloweralkylaminopropyl, each of the loweralkyl groups thereof preferably containing 1 to 4 carbon atoms, e.g., 'y-dimethylaminopropyl; benzyl; substituted benzyl of the formula where X is halogen, preferably chlorine or bromine, loweralkoxy, preferably containing 1 to 3 carbon atoms or loweralkylthio, preferably containing 1 to 3 carbon atoms, and n is a whole number of from 1 to 3, inclusive, e.g., 2,4-dich1orobenzyl, p-bromobenzyl, 3,5-dimethoxybenzyl and 3-chloro-2-ethylthiobenzyl; 4-(1-10weralkyl)piperidyl, the loweralkyl group preferably containing 1 to 4 carbon atoms, e.g., 4-(1-methy1) -piperidyl; 3-(1-loweralkyl)-piperidyl, the loweralkyl group preferably containing 1 to 4 carbon atoms, e.g., 3-(1- ethyl)-piperidyl; 2-(1-loweralkyl)-piperidyl, the lower alkyl group preferably containing 1 to 4 carbon atoms, e.g, 2-(1-propyl)-piperidyl; pyridyl, e.g., a-pyridyl, fipyridyl and -pyridyl; phenyl; substituted phenyl of the formula the group C H?) 11*"NO are as defined above, e.g., 'y-morpholinopropyl, p-piperidinoethyl, fl-thiomorpholinoethyl, and 'y-(l-methyl-4- piperazinyl)propyl;

R is hydrogen or loweralkyl, preferably containing from 1 to 4 carbon atoms, e.g., methyl, ethyl, propyl and butyl;

R" is hydrogen or loweralkyl, preferably containing from 1 to 4 carbon atoms, e.g. methyl, ethyl, propyl and butyl;

R' is hydrogen; loweralkyl, preferably containing from 1 to 4 carbon atoms, e.g., methyl, ethyl, propyl and butyl; or phenyl; provided that when R" and R' are both alkyl they may be linked together to form a homocyclic ring containing from 5 to 6 carbon atoms therein;

R and R are the same or different and represent hydrogen; halogen, preferably chlorine or bromine; loweralkyl, preferably containing 1 to 4 carbon atoms, e.g., methyl, ethyl, propyl and butyl; loweralkoxy, preferlably containing 1 to 4 carbon atoms, e.g., methoxy, ethoxy, propoxy and butoxy; loweralkylthio, preferably containing from 1 to 4 carbon atoms, e.g., methylthio, ethylthio and propylthio; or loweralkylsulfonyl, prefwherein n and erably containing from 1 to 4 carbon atoms, e.g., methylsulfonyl and ethylsulfonyl.

The process for preparing the compounds of structural Formula I may be represented by the following reaction scheme:

or o

and R, R and the nitrogen containing ring are as defined above, by treatment with ammonia or an appropriate amine, or where Y is -OR' or SR' and R is as previously defined, by treatment with an appropriate alcoholate or thioalcoholate (Step 3). The conversion effected by Step 3 is readily accomplished in conventional manner employing conditions generally utilized for carrying out the same. The desired products are readily recovered employing conventional techniques.

The compounds of Formula I, wherein Y is specifically limited to an alkoxy group containing from 1 to 3 carbon atoms (Ia), can additionally be prepared by reacting the 3Hl,4-diazepine-2,5(lI-I,4H)-dione or an appropriately substituted derivative thereof with a trialkoxyfluoborate, e.g., trimethoxyfluoborate, triethoxyfluoborate or tripropoxyfluoborate. This reaction is carried out in conventional manner employing such conditions as are generally applicable for carrying out reactions of this nature. The resulting S-alkoxy derivative is readily recovered in conventional manner. The starting compounds, namely the 3H-1,4-diazepine-2,5-(1H,4H)-dione or appropriately substituted derivatives thereof are either known compounds which can be prepared as described in the literature or compounds which can be prepared in analogous manner. Thus, for example, the starting compounds may be prepared by reacting in known manner an appropriately substituted 3,1 (4H)-benzoxazine-2,4(1H)-dione with methanol to form the corresponding anthranilic acid methyl ester, reacting the latter in known manner with an appropriately substituted bromoacetylbromide or chloroacetylchloride to form the corresponding substituted anthranilic acid methyl ester and treating the latter with ammonia gas. This process may be illustrated as follows:

wherein R, R, R', R and R are as herein defined.

The preceding process is suitable for the preparation of all of the starting compounds employed herein except those which are substituted at the 9- position of the benzene moiety. These latter compounds may be prepared following the procedure described in the J. Medicinal Chem. vol. 9, pp. 6-10 (January 1966). The process set forth therein as well as other processes heretofore described in the literature may also be employed for preparing the starting compounds employed herein.

Representative compounds which can be made in the manner set forth above and are included within the scope of this invention are set forth in tabular form below. For convenience only, the compounds are identified by setting forth the significance of the various groups represented in structural Formula 1. However, it is to be understood that the designation of the compounds in this manner is merely in lieu of setting forth the chemical name thereof.

Compound R R R R R Y 1 a. methyl H H H 7-chloro -NH1 2 c. methyl H H H 'I-chloro NHCH I 0 11 3 methyl H H H 7-chl0r0 N 4 propyl H H H 7-cl1loro -'-NHCH2CH=CH1 Compound R R" R R RV Y 0211: 5 methyl H H H 7-chlor0 N\ C H2O E C H 6 butyl H H H 7-0111010 -NHCH2CH2N (CHs) a /C H; 7 methyl H H H 7-chloro -N\ /C H;

N(0 t)eN 8 ethyl H H H 7-chloro -NHCH2 ICHE (I31 9 methyl H H H 7-cll10r0 -N-ol Cl /CH9 10 isopropyl H H H 7-chl0ro N l 11 meth l H H H 7-chl0ro -N@ CH} f N 12 meth l H H H 7-chl0ro -N 1s meth l H H H 7-cl1l0r0 N N C H3 5 14 eth l H H H 7-chl0r0 4:0

C H3 1 15 meth l H H 7-ch1or0 N@ N LE, I 11: 16 propyl H H H 7-chl0ro N (I) 0 H3 17 methyl H H H 7-chloro NH I O 0 Ha 18 isopropyl H H H 7-chloro -O 0 H 19 methyl H H II 7-chlol-o -O C2H5 20 utyl H H H 7-chl0ro 0 CH (CH 1 2L. methyl H H H 7-chl0ro 04H.)

/C H; 22 methyl H H H 7-chlor0 0 CH; CHlN Compound R R" 3" R R Y H H H H -NH2 H H H H -N H C Ha H H H H N C He) 2 H H H H -NH H H H H -NHOH:CH2N(CH3)2 H H H H NHCHg- H H H H -'O OH: H H H H --O C 4H9 H H H H (C 2)3N(CH3)g eamethyl H H II -ocm 64 methyl H H H H -S 0 H1 65 e methyl H H H H 'S C Hz) 1N 0 H3) 9 66- methyl H H H H --s-@ 67. meth l H H H H SCH2 68 methyl H H H H 69 methyl H H H H -N N OH 70 methyl H H H H NH 0 H2) er-N 2) 71- methyl H H H H 0 (CHt) -N 72.. methyl H H H H -S(CH2)2N NCH 73 methyl H H H H --NH C H2) 2-N 74 methyl H H H H -N H 0 Hz) z-N S 75 methyl methyl H 7-chloro 8-chloro -NHCH3 C H 76 methyl H phenyl 7-methyl H N 77 eth l H methyl 7-methylthlo H -NHCHz- 7s meth l H eth l 7-methyl S-methyl -NH@ 79 methyl H H 7-methoxy H -N 80 methyl H methyl 7-methylsulfonyl H 0 0 H3 81 methyl methyl methyl 7-methoxy H O CHzCHzN CH 3 s2 ethyl H H G-chloro H -0-@ 83 methyl methyl 7-chloro S-methoxy -OCHz- 84 methyl H phenyl 7-metll0xy S-methoxy SCH s5 methyl methyl eth l 7-chloro H -s@ 86 methyl methyl phenyl 7-chloro H SQ Compound R R R RIV RV Y 87 methyl H H 7-chloro S-methyl -S(CH2)3N(CHs)2 88 ethyl H methyl 7-chloro 9-ohloro -N N-CH;

89 methyl H ethyl 7-bromo H NH(CH2)3N/ b 90 methyl methyl methyl 7-bromo 9-bromo N\ (C 2)s a)2 91 methyl H H 7-methyl 8-methylsulfonyl -O(CHz) --N 92 methyl H methyl 6-methyl 8-methylthio S(CH;) -N N-CH;

93- methyl H H H 7-ethoxy 1 94 methyl methyl methyl H H --N 95 methyl methyl methyl fi-methyl 7-chloro -SCH5 96.-..-- methyl methyl phenyl 7-bromo S-methyl C2H5 Q7 methyl methyl methyl 7-ch1oro H NHCH2CH=CH2 3 98 methyl methyl methyl 7-ehloro S-ehloro -N 99 methyl ethyl ethyl 7-ehloro H -NHC2H5 The compounds of structural Formula I are useful Ingredient: Parts by weight because they possess pharmacological activity. In par- 4 7-chloro-5-ethoxy 1 methyl-3H-l,4-benzodiaticular, all of the compounds possess central nervous sys- O zepin-2-(lH)-one (or pharmaceutically actem activity and therefore can be used as tranquilizers or ceptable salt thereof) 15 antidepressants depending on whether they depress or Tragacanth 2 stimulate the central nervous system. Thus, for example, Lactose 74.5 compounds of the type of Example 9 depress the central Corn Starch nervous system and are useful as tranquilizers whereas 45 Talcum 3 compounds of the type of Examples 1, 5 and 7 stimulate Magnesium Stearate 0.5

the nervous system and therefore find application as antidepressants. The determination as to whether a particular compound is a tranquilizer or antidepressant can be readily established by standard test procedures with minimal effort.

For the above uses the compounds may be combined with a pharmaceutically acceptable carrier, and such other conventional adjuvants as may be necessary and administered orally in such forms as tablets, capsules, elixirs, suspensions, solutions and the like or parenterally in the form of an injectable solution or suspension. The compounds may be administered in their free base form or in the form of a pharmaceutically acceptable acid addition salt thereof. Such salts possess the same order of activity as the free base, are readily prepared by reacting the base with the appropriate acid in conventional manner and accordingly are included within the scope of this inyention. Representative of such salts are the mineral acid salts such as the hydrochloride, hydrobromide, phosphate, sulfate and the like and the organic acid salts such as the fumarate salicylate, succinate, maleate, methanesulfonate and the like. The dosage employed will, of course, vary depending upon the compound used, the therapy desired .and the mode of administration. However, in general satisfactory results are achieved when administered at a daily dosage of from about to about mg.

A representative formulation is a tablet prepared by standard tabletting techniques and containing the following ingredients:

1 Calculated as free base.

The following examples show representative compounds encompassed within the scope of this invention and the manner in which such compounds are prepared. However, it is to be understood that the examples are for purposes of illustration only and are not intended as in any way limiting the scope of the invention which is defined in the appended claims.

In the examples which follow all temperatures are in degrees centigrade and the parts and percentages are 'by weight unless otherwise specified.

Example 1.-7-chlorol-methyl-5-(3 dimethylaminopropylamino)-3H-1,4-benzodiazepin-2(lH)-one CH; 0 at A. Preparation of 5-chloro-Nbrornoacetyl-N-methylanthranilic acid methyl ester.Cool to 0 C. a solution of 0.02 mole of S-chloro-N-methylanthranilic acid methyl ester in 100 parts by volume of dichloromethane. To the solution add 0.025 mole of bromoacetylbromide in 40 13 parts by volume of dichloromethane. While maintaining the temperature of the resulting mixture at from C. to C., add dropwise thereto 0.03 mole of pyridine in 15 parts by volume of dichloromethane. After stirring for one-half hour at 0-5 C., extract the mixture with 2 N hydrochloric acid, then with water and then with aqueous sodium bicarbonate solution. Dry the organic phase and evaporate the solvent therefrom to obtain 5-chloro-N- bromoacetyl-N-methylanthranilic acid methyl ester as a colorless oil, B.P. 151 to 153 C./0.05 mm. Allow the oil to stand at 0 C. for 19 hours to obtain crystalline material, M.P. 58 59 C.

B. Preparation of 7-chloro-1-methyl-3H-1,4-benzodiazepin-2,5-(1H,4H)-dione.-Dissolve 4.4 parts of S-chloro- N-bromoacetyl-N-methylanthranilic acid methyl ester in 100 parts by volume of methanol. Saturate the resulting solution (while stirring and cooling to C.) for two hours with ammonia gas. Strip olf the solvent and dissolve the residue in a minimum of chloroform. Wash the resulting solution first with 2 N hydrochloric acid, then with water and then with aqueous sodium bicarbonate solution. Dry the chloroform solution and evaporate the sol vent therefrom to obtain the product. Recrystallize from methanol to obtain 7-chloro-1-methyl-3H-1,4-benzodiazepine-2,5(1H,4H)-dione, M.P. 178 to 179 C.

C. Preparation of 5,7-dichloro l methyl-3H-1,4-benzodiazepin-2-(1H)-one hydrochloride.Dissolve 1.14 parts (0.005 mole) of phosphorus pentachloride in 50 parts by volume of carbon tetrachloride. Add dropwise to the resulting solution a solution of 1.125 parts (0.005 mole) of 7-chloro-1-methy1-3I-l-l,4-benzodiazepin-2,5 (1H,4H)-dione in 5 parts by volume of chloroform and 20 parts by volume of carbon tetrachloride. The product crystallizes out. Reflux for minutes to complete the reaction before filtering the suspension. Wash the solids with carbon tetrachloride and dry for 2 hours at 40 C. to obtain 5,7-dichloro-l-methyl-3H 1,4 benzodiazepin 2 (1H)-one hydrochloride, M.P. 7080 C. (dec.).

D. Preparation of 7-chloro-1-methyl-5-(3-dimethylaminopropylamino)-3H-1,4 benzodiazepin-2(1H)-one.- Dissolve 11.0 parts of N,N-dimethyl-1,3diaminopropane in 75 parts by volume of dichloromethane and cool the resulting solution to 0 C. To this solution (while stirring and maintaining the temperature at from 0 to 5 C.) add a solution of 10 parts of 5,7-dichloro-1-methyl-3H-l,4- benzodiazepin-2-(lH)-one hydrochloride in 250 parts by volume of dichloromethane. Permit the resulting solution to warm to room temperature C.), maintain at that temperature over night (17 hours) and then strip off the solvent. Dissolve the residue in chloroform, wash the chloroform solution with aqueous sodium bicarbonate solution, dry the washed solution over sodium sulphate and evaporate the solvent to obtain 7-chloro-1-methyl-S(3- dimethylaminopropylamino) 3H 1,4 benzodiazepin- 2( 1H)-one.

To obtain the dihydrochloride salt thereof, wash the free base several times with petroleum ether and add to the 'Washed residue an ethanolic solution of hydrogen chloride (containing two molar equivalents of hydrogen chloride). Recrystallize from methanol to obtain the dihydrochloride, M.P. 268 C. (dec.).

Example 2 Following the procedure of Step D of Example 1 and employing an equivalent amount of the ractants enumerated below in place of the N-N-dimethyl-1,3-diamino-propane used therein there are obtained the products set forth below.

amino) -3H-1,4-benzodiazepin- 2 1H) -one.

Benzylamine 7-chloro-l-methyl-5-(benzylamino) -3H-1,4-benzodiazepin- 2( 1H) -one. p-Chlorobenzylamine 7-chloro-1-methyl-5-(p-chlorobenzylamino)-3H-1,4-benzodiazepin-Z 1H) -one. 3,5-dimethoxybenzylamine 7-chloro-1-methyl-5-(3,5-dimethoxybenzyla-mino) -3H-1,4- benzodiazepin-2(1H)-one. 4-amino-1-methylpiperidine 7-chloro-1-methyl-5-(1-methyl- 4-piperidyl)amino-3H-l,4- benzodiazepin-2( 1H)-one. Z-aminopyridine 7-chloro-1-methyl-5-(2-pyridylamino)3H-1,4-benzodiazepin- 2(1H)-one. p-Chloroaniline 7-chloro-l-methyl-S-(p-chlorophenylamino)-3H-1,4-benzodiazepin-2( 1H) -one. Ethylbenzylamine 7-chloro-l-methyl-S-(N-methyl- N-benzylamino)-3H-1,4-benzodiazepin-Z 1H) -one.

Example 3.7-chl0ro-5-('y-morpholinopropylamino)-1- methyl-3H-1,4-benzodiazepin-2( 1H) -one Newton-N00 Add a solution of 2.4 parts of phosphorous pentachloride in parts by volume of dichloromethane to a solution of 2.24 parts of 7-chloro-l-methyl-3H-l,4- benzodiazepin-2,5(1H,4H)-dione in 50 parts by volume of dichloromethane and maintain the resulting mixture at 20 C. for two hours. Remove the phosphorous oxychloride generated and solvent by heating in vacuo at a temperature of from 30 to 40 C. Dissolve the residue in 20 parts by volume of dichloromethane and add the resulting solution dropwise to a solution of 2.0 parts of 'y-aminopropylmorpholine in 50 parts by volume of dichloromethane while cooling in a Dry Ice/acetone bath. Maintain the mixture at room temperature over night (17 hours), then pour it into ice water containing 5 parts of sodium bicarbonate and separate the resulting layers. Chromatograph the organic layer containing the crude base on a silica gel column using chloroform as the solvent to obtain 7-chloro-5-(' -morpholinopropylamino)-1- methyl-3H-1,4-benzodiazepin-2( 1H) -one.

To obtain the dihydrochloride salt thereof, dissolve the free base in isopropanol, neutralize with an isopropanol solution of hydrogen chloride and cool. Recrystallize from ethanol-diethylether to obtain the dihydrochloride, M.P. 275 C. (dec.).

Example 4 Following the procedure of Example 3 and employing an equivalent amount of the reactants enumerated below in place of the v-aminopropylmorpholine used therein there are obtained the products listed below.

Reactant: Product l-(fl-aminoethyl) piperidine 7-chloro-5-(fl-piperidinoethyl- 0113 1. Q \CH, 01

l N-CHa Dissolve 26.0 parts of N-methylaniline in 150 parts by volume of dichloromethane and cool the solution to 0 C. While stirring and maintaining the temperature at from 0 to C. add a solution of parts of 5,7-dichloro-1- methyl 3H 1,4-benzodiazepin-2(1H)-one hydrochloride in 250 parts by volume of dichloromethane. Allow the resulting solution to warm to room temperature, maintain at that temperature over night and then strip off the solvent. Dissolve the residue in chloroform, wash the chloroform solution with aqueous sodium bicarbonate solution, dry the solution over sodium sulfate and evaporate the solvent to obtain 7-chloro-l-methyl-S-(N-methylanilino)-3l-I-l,4-benzodiazepin-2(1H)-one.

To obtain the hydrochloride salt thereof wash the base several times with petroleum ether and neutralize with an ethanolic solution of hydrogen chloride. Recrystallize from methanol to obtain the hydrochloride, MP. 273 275 C.

Example 6 Following the procedure of Example 5 and employing an equivalent amount of the reactants enumerated below for the N-methylaniline used therein there are obtained the products listed below.

Reactant: Product 3,5-dimethoxybenzylamine 7-ch1oro-1-methyl-5-(3,5-di- Example 7.7-chloro-1-methyl-5-(N-methylpiperazino)- 3H-l,4-benzodiazepin-2( 1H)-one Dissolve 11.0 parts of N-methylpiperazine in parts by volume of dichloroethane and cool the resulting solution to 0 C. To the cooled solution (while stirring and maintaining the temperature at 05 C.- add a solution of 10 parts of 5,7-dichloro-1-methyl-3H-1,4-benzodiazepin-2(1H) )-o11e hydrochloride in 250 parts by volume of dichloromethane. Allow the resulting solution to warm to room temperature, maintain at room temperature over night and then strip oi the solvent. Dissolve the residue in chloroform, wash the chloroform solution with aqueous sodium becarbonate solution, dry the washed solution over sodium sulphate and evaporate the solvent to obtain 7-chloro-1-methyl 5 (N-methylpiperazinyD-3H- l,4-benZodiazepin-2(1H)-one, M.P. 171 C.

Example 8 Following the procedure of Example 7 and employing an equivalent amount of the reactants enumerated below in place of N-methylpiperazine there are obtained the products listed below.

Reactant: Product Imidazoline 7-chlorol-methyl-S l-imidazolidinyl -3H- 1 ,4-benzodiazepin- 2 1H) -one.

Pyrazolidine 7-chl0ro-l-methyl-5-( 1- pyrazolidinyl) -3H- 1,4-benzodiazepin- =2 1H) -one.

T hiamorpholine 7-chloro-1-methyl-5-(thiomorpholino) -3H-1,4-benzodiazepin- 2 1H) -one.

Morpholine 7-chloro-1-methyl-5-(morpholino -3H- 1 ,4-benzodiazepin-2 1H) -one.

Example 9.-7-chloro-5-ethoxy-l-methyl-3 H-1 ,4- benzodiazepin-2( 1H) -one I O CzHs Prepare triethoxyfiuoborate in known manner [H. Meerwein, I. Prakt. Chem. 154, 83 (1939)] from 5.0 parts of boron trifluoride etherate (47%) and 2.5 parts of epichlorohydrin. Dissolve the fiuoborate in 50 parts by volume of chloroform. Cool the solution to '0" C. and then add thereto a solution of 5.57 parts of 7-chloro-1-methyl-3H- l,4-benzodiazepin-2,5(lH,4H)-dione in parts by volume of chloroform. Maintain the resulting mixture over night at room temperature and then add 10 parts by volume of 50% aqueous potassium carbonate solution. Separate the organic phase, dry the same over potassium carbonate and evaporate the solvent to obtain crystalline 7-chloro-5-ethoxy-1-methyl-3H-1,4 benzodiazepin-2 (1H)-one, M.P. l23.5-124.5 C.

Example 10.-7-chloro-5-methoxy- 1-methyl-3H- 1,4- benzodiazepin-2(1H)-one OCH;

Following the procedure of Example 9 and employing an equivalent amount of trimethoxyfiuoborate (prepared in known manner) in place of the triethoxyfluoborate used therein there is obtained the product 7-chl0ro- Example 1 1.7-chloro-5-ethoxy-1-ethyl-3H-1,4- benzodiazepin-2( 1H) -one A. Preparation of S-chloro-N-bromoacetyl-N-ethylanthranilic acid methyl ester.Following the procedure of Example 1, Step A, and employing an equivalent amount of 5-chloro-N-ethylanthranilic acid methyl ester in place of the S-chloro-N-methylanthranilic acid methyl ester used therein there is obtained the product S-chloro-N- bromoacetyl-N-ethylanthranilic acid methyl ester, B.P. 130 C/0.01 mm.

B. Preparation of 7-chloro-l-chloro-l-ethyl 3H-l,4- benzodiazepin-2,5-(1H,4H)dione.-Following the procedure of Example 1, Step B, and employing an equivalent amount of S-chloro-N-bromoacetyl-N ethylanthranilic acid methyl ester in place of the S-chloro-N-bromoacetyl- N-methylanthranilic acid methyl ester used therein there is obtained the product 7-chloro-1-ethyl-3H-1,4-benzodiazepin-2,5-(1H,4H)-dione, M.P. 146-147 C.

C. Preparation of 7-chloro-5 ethoxy-1-ethyl-3H-1,4- benzodiazepin-2(1H)-one.-Following the procedure of Example 9 and employing an equivalent amount of 7- chloro-1-ethyl-3H-1,4-benzod-iazepin 2,5-(lH,4H)-dione in place of the 7-chloro-1-methyl-3H-1,4-benzodiazepin- 2,5-(1H,4H)-dione used therein there is obtained the product 7-chloro-5-ethoxy-1-ethyl-3H-1,4-benzodiazepin- 2(1H)-one, M.P. 9193 C.

Example 12.--7-chloro-1-methyl-5-thiophenyl-3H-1,4- benzodiazepin-2( 1H) -one Reflux gently for 2 hours 2.24 parts of 7-chloro-1-methyl-3H-l,4-benzodiazepin-2,5-(1H,4H)-dione with a solution of 2.4 parts of phosphorous pentachlon'de in 100 parts by volume of dichloromethane. Evaporate in vacuo the phosphorous oxychloride generated and the solvent. Dissolve the residue in 50 parts by volume of dichloromethane. Under an atmosphere of nitrogen add the resulting solution slowly to a solution of 0.5 part of sodium in 2 parts by volume of thiophenol and 50 parts by volume of dry tetrahydrofuran (cooled to 70 C. in a Dry Ice/ acetone bath). Maintain the resulting mixture under a nitrogen atmosphere at room temperature over night, then pour into ice water and then extract the resulting mixture with dichloromethane. Chromatograph the resulting crude product on a silica gel using chloroform as a solvent to obtain crystalline 7-chloro-1-methyl-5-thiophenyl-3H-1,4- benzodiazepin-2(1I-I)-one (middle fraction). Recrystallize from methanol to obtain product, M.P. 147 C.

Example 13 Following the procedure of Example 12 and employing the reactants enumerated below in place of the thiophenol used therein there are obtained the products listed below.

Reactant: Product Methylmercaptan 7-ch1oro-1-methyl-5-methylthio- 3H-l,4-benzodiazepin-2(1H)- one.

2-propyn-1-thiol 7-chloro-l-methyl-S-propargylthio-3H-1,4-benzodiazepin-2 (1H)-one.

2-propen-1-thiol 7-chloro-l-methyl-S-allylthio- 3H-1,4-benzodiazepin-2( 1H) one.

Benzylmercaptan 7-chloro-l-methyl-S-benzylthio- 3H-1,4-benzodiazepin-2(1H)- one.

Example 14.-7-chloro-S-ethylenimino-l-methyl-3H- Add a solution of 2.4 parts of phosphorous pentachloride in parts by volume of dichloromethane to a solution of 2.24 parts of 7-chloro-1-methyl-3H-1,4- benzodiazepin-2,5(1H,4H)-dione in 50 parts by volume of dichloromethane and maintain the resulting mixture at 20 C. for two hours. Remove the phosphorous oxychloride generated and the solvent in vacuo at a temperature of from 30 to 40 C. Dissolve the residue in 20 parts by volume of dichloromethane and add the resulting solution dropwise to a solution of 2.0 parts of ethylenimine in 50 parts by volume of dichloromethane while cooling in a Dry Ice/acetone bath. Maintain the mixture at room temperature over night (17 hrs.) and then pour it into ice water containing 5 parts of sodium bicarbonate. Separate the organic layer and distil off therefrom the excess ethylenimine in vacuo to obtain 7- chloro-S-ethylenimino-l-methyl 3H 1,4-benzodiazepin- 2(1H)-one.

To obtain the hemifu-marate salt thereof, neutralize the free base with an ethanolic solution of fumaric acid. Recrystallize from ethanol to obtain the hemifumarate, M.P. 224.5 -225.0 C. (dec.).

Example 15 Following the procedure of Example 14 and employing an equivalent amount of the reactants enumerated below in place of the ethylenimine used therein there are obtained the products listed below.

1 9 What is claimed is: 1. A compound of the formula R C=N wherein R represents lower alkyl;

R represents lower alkyl; R" represents hydrogen or lower alkyl; R represents hydrogen, lower alkyl or phenyl; and

each of R and R independently, represents hydrogen,

20 halo, lower alkyl, lower alkoxy, lower alkylthio, or lower alkylsulfonyl.

10 References Cited UNITED STATES PATENTS 3,346,565 10/1967 Testa et a1. 260-239.3

15 HENRY R. JILES, Primary Examiner.

ROBERT T. BOND, Assistant Examiner. 

